7/27/2023 0 Comments High amniotic fluid levels![]() ![]() Īmniotic fluid EPO levels are strongly correlated with umbilical plasma EPO concentrations in both normal and abnormal pregnancies, including diabetic pregnancies, before the onset of labour. The depletion of iron stores in fetal liver, brain and heart in stillborn fetuses of diabetic mothers suggests that chronic fetal hypoxia precedes fetal death in the majority of cases. ![]() This is further supported by the polycythaemia and increased nucleated red cells often observed in the fetuses and newborn infants of diabetic women. Fetal plasma and amniotic fluid erythropoietin (EPO) levels are also frequently elevated, suggesting an increased incidence of chronic fetal hypoxia in pregnancies complicated by diabetes. Conclusions/interpretationĪntenatal high amniotic fluid erythropoietin levels can identify Type 1 diabetic pregnancies at increased risk of severe perinatal complications.Ībnormal fetal heart rate, cord blood acidosis and low Apgar scores occur more often in diabetic pregnancies than in non-diabetic pregnancies, indicating an increased risk of intrauterine hypoxia. Low umbilical artery pO 2 (<15.0 mm Hg) was explained by amniotic fluid erythropoietin ( p<0.0001) and birthweight z score ( p=0.004). Multivariate logistic regression analysis revealed that amniotic fluid erythropoietin was the only variable independently related to low umbilical artery pH (<7.21 p<0.0001) and neonatal hypoglycaemia ( p=0.002). The median amniotic fluid erythropoietin level was 14.0 mU/ml (range 2.0–1975.0) in diabetic pregnancies and 6.3 mU/ml (range 1.7–13.7) in controls ( p63.0 mU/ml) than in those with normal levels. The amniotic fluid erythropoietin concentration was measured in 156 diabetic singleton pregnancies at a median time of 1 day before Caesarean section without labour contractions and in 19 healthy control subjects at Caesarean section. ![]() MethodsĪ total of 331 women with Type 1 diabetes had at least one childbirth between 19. In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in Type 1 diabetic pregnancies. ![]()
0 Comments
Leave a Reply. |